In the past couple of decades, cultured pearls have been produced using larger oysters in the south Pacific and Indian Ocean. The largest pearl oyster is the Pinctada maxima, which is roughly the size of a dinner plate. South Sea pearls are characterized by their large size and warm luster. Sizes up to 14 mm in diameter are not uncommon. South Sea pearls are primarily produced in Australia,tahitian pearl Indonesia and the Philippines.

Mitsubishi commenced pearl culture with the south sea pearl oyster in 1916, as soon as the technology patent was commercialized. By 1931 this project was showing signs of success, but was upset by the death of Tatsuhei Mise. Although the project was recommenced after Tatsuhei's death, the project was discontinued at the beginning of WWII before significant productions of pearls were achieved.

After WWII, new south sea pearl projects were commenced in the early 1950s in Burma and Kuri Bay and Port Essington in Australia.south sea pearl Japanese companies were involved in all projects using technicians from the original Mitsubishi south sea pre-war projects.

5,cure the various 疮 inside:three moneys of pearl, the borax,green 黛 each one money, a five centses of ice, in the golden thread,person the white each two money.(the 煅 lead)Up is a thin end, any inside the various 疮 is all can 掺 it.(《The 丹 set jade case 》the jewelry spread) 6,cure the eye long accumulate the 顽翳 , cover the 覆瞳 the person:pearl 12, a 榆 32(锉 ).With the water two major,freshwater pearl together cook to the water to the utmost, take out the pearl, immerse with the vinegar five in the days to come, have no vinegar spirit with the hot water 淘 ream, then grind ream very thin.Each time with the copper 箸 , take a little bit few 翳 up, take 瘥 as the degree.(《Saint 惠 square 》) 7,cure to living the red vein in the hot eye of the breeze, hurtle the black 睛 of the member, and have HUA YI4:the pearl penny, the cent of the dragon brain half, the amber penny, the cent of the vermilion cinnabar half, two beans of borax are strong.Together thin grind such as the powder.Three and five degrees of everyday, take with the copper 箸 few, order on the 眦 .(《The saint 惠 is square 》the pearl spread)

8,cure the various poisonous 疽疮 of everything, wear the 筋溃络 , the lousy muscle 损 bone, break to close a stanza, the bloody pus pours the 漓 , the 溃 is long and do not accept of certificate:the pearl one money(grind the very thin end), placenta a(dry dry, grind the very thin end);white wax 12, the pig fat oil 12, totally melt on the fire with going into the placenta end,the pearl end, adjust evenly.First pour to wash the poisonous 疮 with the pig's knuckles soup clean, the wax oil medicine, lightly spread up, stick it with the ceruse hemp seed oil medicated plaster again.(《This grass remits the speech 》oil wax cream) 9,cured the 疳 skin 损 meat lousy, the pain hardest endures, and various 疮 the new meat is already full,pearl factory can't peltry, again the soup sprinkles the fire to burn the skin 损 meat lousy, the not only of the ache:the green urn spends five cents, the pearl one money(grind very thin), true light powder 12.Last three flavors totally the thousandth year in graduate school turn, thin if fly the noodles.Any descends the 疳 beginning to rise the skin 损 , 搽 it;the putrefied ache, the licorice soup wash clearly, the pig spinal cord adjust